View or download the n,ndimethylformamide msds material safety data sheet or sds for from merck. View or download the n,ndimethylformamide msds material safety data sheet or sds for 103034 from merck. Dimethylformamide dmf is a clear, colorless, hygroscopic liquid with a slight amine odor. Paul dimarco, vice president quality management for industrial or lab use only. Companies may have immediate legal obligations following the inclusion of a substance in the candidate list on this website including in particular articles 7, 31 and 33 of the reach regulation. Uses advised against food, drug, pesticide or biocidal product use. N,ndimethylformamide product number d 4551 store at room temperature product description molecular formula. It is a volatile organic compound and a member of formamides. It can harm the eyes, skin, lungs, liver, and heart.
The resource to the url or file is currently unavailable rated 5 out of 5 by sm from various publications cite the use of n various publications cite the use of n,ndimethylformamide dmf as a solvent for many hydrophobic organic compounds. N, n dimethylformamide dmf is a solvent with a low evaporation rate, useful for preparing solutions with a variety of hydrophobic organic compounds used in molecular biology applications. Each 7th edition documentation summarizes and evaluates the. It is used in the chemical industry as a solvent, a chemical intermediate, and an additive. N,n dimethylformamide is a derivative of formamide, whereby the amino hydrogens are replaced by methyl groups. Dmf is a useful solvent employed for the isolation of chlorophyll from plant tissues. Listed as a hazardous air pollutant hap generally known or suspected to cause serious health problems. The user must determine suitability of this information for his application. N,ndimethylformamide d4551 product information sheet. N,n dimethylformamide is listed in the tsca inventory and in sara 3. Buy n,ndimethylformamide azine dihydrochloride cas 868670466, a biochemical for proteomics research, from santa cruz.
Chemical product and company identification product name. However, when dmf is stored in air, it deteriorates slowly absorbing moisture, and releasing dimethylamine. Workers may be harmed from exposure to dimethylformamide. This material does not contain any class 1 ozone depletors. N,ndimethylformamide azine dihydrochloride cas 868670. The solvent properties of dmf are particularly attractive because of the high dielectric constant, the aprotic nature of the solvent, its wide liquid range and low volatility. Identification product name n,ndimethylformamided7 casno 4472417 synonyms no information available recommended use laboratory chemicals. Maltodextrin maltodextrin side effects applications and uses of maltodextrin halal certified maltodextrin kosher certified maltodextrin is maltodextrin gluten free. This documentation is available for download in pdf format. Product name n,n dimethylformamide d7 casno 4472417 synonyms no information available recommended use laboratory chemicals. It is frequently used for chemical reactions and other applications, which. List of all languages of msds for eastmantm 2ethylhexanol. Material safety data sheet n,ndimethylformamide msds.
The resulting fully cured polyurethane resin is a solid film or skin that is considered harmless. It plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst. Commonly abbreviated as dmf although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate, this colourless liquid is miscible with water and the majority of organic liquids. Tlvr chemical substances 7th edition documentation acgihr format. Section 1 n,ndimethylformamide 1 chemical product and company identification msds name. It has a role as a polar aprotic solvent and a hepatotoxic agent. Only the candidate list published on this website is deemed authentic.
N,ndimethylformamide cas 68122 822275 emd millipore. N,n dimethylformamide 68122 hazard summary dimethylformamide is used as an industrial solvent and in the production of fibers, films, and surface coatings. Atomatom radial pair distribution functions calculated for pure dmf systems between a acyl oxygen o a acyl carbon c a and b acyl oxygen o a acyl hydrogen h a using parameters from caleman et al. May also indicate that the same chemical with the same cas number appears on another list with a different chemical name. N,n dimethylformamide is considered to be a potent liver toxin. Dmf dimethylformamide is a recommended solvent for labeling reactions using nhs esters. Thermo scientific pierce dimethylformamide dmf is a sequencinggrade preparation with high purity and consistent absorptivity properties for use in hplc and mass spectrometry methods.
Its health effects include hepatotoxicity and male reproductoxicity, possibly linked with mitochondrial dna mtdna alterations including mtdna common deletion deltamtdna4977 and. Symptoms of acute exposure in humans include abdominal pain, nausea. N,n dimethylformamide dmf is the commonly employed solvent for chemical reactions. Safety data sheet northwest missouri state university. N,n,dimethylformamide is produced, as an intermediate or a final product, by process units covered under this subpart.
N,n dimethylformamide is a member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups. N,ndimethylformamide is considered to be a potent liver toxin. Please note that certain data fields will be generic and may or may not reflect the information relevant to the recipient andor the materialpackage size including but not limited to the manufacturersupplier address. None information in this msds is from available published sources and is believed to be accurate. Not intended for use as a disinfectant as defined by the epa. Pronunciation of dimethylformamide with 2 audio pronunciations, 1 meaning, 8 translations and more for dimethylformamide. Msds dimethylformamide page 1 of 9 material safety data sheet. Draft background document for n,n dimethylformamide dmf. Dimethylformamide is odorless, but technicalgrade or degraded samples often. Safety data sheet creation date 12jan2015 revision date 19jan2018 revision number 4 1. These impurities rapidly destroy nhs ester function, decrease labeling efficiency, and. Hconch32 material safety data sheet n,ndimethylformamide msds. Identification product name n,n dimethylformamide d7 casno 4472417 synonyms no information available recommended use laboratory chemicals. Force field parameters for n,ndimethylformamide dmf.
N,ndimethylformamide msds material safety data sheet or sds, coa and coq, dossiers, brochures and other available documents. This sequencinggrade dimethylformamide is specially purified by a proprietary method and tested to ensure lottol. Chemtrec 8004249300 outside usa 7035273887 1216 6th ave n kent wa 98032 phone. N,ndimethylformamide included in the candidate list of substances of very high concern svhc. Material safety data sheet n,ndimethylformamide msds section 1. Tlvr chemical substances 7th edition documentation. Sds of n,ndiethylformamide, safety data sheets, cas 617845. Intrinsic properties n,n dimethylformamide dmf was identified as a substance of very high concern svhc according to article 57 c as it is classified in annex vi, part 3. The level of exposure depends upon the dose, duration, and work being done. Msds contains all the information required by the cpr. Acetylene, dissolved in dmf safety data sheet sds p6201 praxair. P280 wear eye protection, face protection, protective clothing, protective gloves.
Dimethylformamide solvent for peptide coupling, used as a wash after each deprotection and coupling step in tboc, used as a solvent in fmoc, solvent with low evaporation rate, catalyst in synthesis of acid halides. Acetone safety data sheet according to federal register vol. Hazardous in case of skin contact irritant, permeator, of. Eye contact contact with dimethylformamide may cause moderate to severe irritation, tearing, pain, corneal opacity, or temporary corneal injury. Toxicity data skin rabbit 4,720 mgkg ld50 oral rat 2,800 mgkg ld50 6 hr. Details of the supplier of the safety data sheet emergency telephone number for information us call. Not intended as an active substance in food or drug.
Application n,n dimethylformamide was used to solubilize mtt crystals in cell viability assays. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Further experience with the rangefinding test in the industrial toxicology laboratory. N,ndimethylformamide azine dihydrochloride cas 868670466. Dimethylformamide an overview sciencedirect topics. Intrinsic properties n,ndimethylformamide dmf was identified as a substance of very high concern svhc according to article 57 c as it is classified in annex vi, part 3.
P271 use only outdoors or in a wellventilated area. Sections i health hazard assessments for noncarcinogenic effects and. Dimethylformamide is an organic compound with the formula ch 3 2 ncoh. Dimethylformamide dmf is a widely used solvent used in the synthetic resin and leather industries that causes doserelated massive necrosis in animals 3 and is capable of producing focal hepatic necrosis and microvesicular steatosis in humans, the severity of which correlates.
Kleiner, in macsweens pathology of the liver seventh edition, 2018. Chemical information document for dimethylformamide dmf. Eye contact contact with dimethylformamide may cause moderate to severe irritation, tearing, pain, corneal opacity, or. No warranty, express or implied, is made and labchem inc. Dmf, dmfa1 this product is designated as molecular biology grade. N,ndimethylformamide dmf is a multipurpose organic compound with burgeoning usage. Improved prediction of bulk properties and complete miscibility in water. N,ndimethylformamide candidate list of substances of. N,ndimethylformamide 68122 hazard summary dimethylformamide is used as an industrial solvent and in the production of fibers, films, and surface coatings. Force field parameters for n,ndimethylformamide dmf revisited. It is widely employed reagent in organic synthesis. Dmf or dmfa dmf is an organic solvent produced in large quantities throughout the world. In one of its main uses in organic synthesis, dmf was a reagent in the vilsmeierhaack reaction, which is used to formylate aromatic compounds.